Type III ANOVA on main and interaction effects, and LM model summaries.
Prolactin
Chisq
Df
Pr(>Chisq)
(Intercept)
250.7924480
1
<0.0001
***
Study
3.2136720
1
0.07
ns
f39_gdm_new
0.5754347
1
0.4
ns
BMI
3.3368238
1
0.07
ns
Ethnicity_cauc
105.4219556
1
<0.0001
***
f10c_any_cig_1st_vst
49.1590682
1
<0.0001
***
GA_samp
164.6323095
1
<0.0001
***
Study:f39_gdm_new
1.8652579
1
0.2
ns
HPL
Chisq
Df
Pr(>Chisq)
(Intercept)
150.8759535
1
<0.0001
***
Study
7.3986291
1
0.007
**
f39_gdm_new
0.4357432
1
0.5
ns
BMI
236.2094019
1
<0.0001
***
Ethnicity_cauc
5.5165373
1
0.02
*
f10c_any_cig_1st_vst
0.9176455
1
0.3
ns
GA_samp
2601.9722143
1
<0.0001
***
Study:f39_gdm_new
1.4845286
1
0.2
ns
GH2
Chisq
Df
Pr(>Chisq)
(Intercept)
251.096669
1
<0.0001
***
Study
1.107622
1
0.3
ns
f39_gdm_new
1.386104
1
0.2
ns
BMI
87.622496
1
<0.0001
***
Ethnicity_cauc
3.246832
1
0.07
ns
f10c_any_cig_1st_vst
1.039153
1
0.3
ns
GA_samp
1032.266869
1
<0.0001
***
Study:f39_gdm_new
3.376951
1
0.07
ns
Insulin
model term
df1
df2
F.ratio
Chisq
p.value
1
Study
1
Inf
21.326
21.326
<0.0001
***
3
f39_gdm_new
1
Inf
33.726
33.726
<0.0001
***
4
BMI
1
Inf
330.722
330.722
<0.0001
***
5
Ethnicity_cauc
1
Inf
25.046
25.046
<0.0001
***
6
f10c_any_cig_1st_vst
1
Inf
3.158
3.158
0.08
ns
7
GA_samp
1
Inf
2.506
2.506
0.1
ns
2
Study:f39_gdm_new
1
Inf
4.089
4.089
0.04
*
HOMA.IR
model term
df1
df2
F.ratio
Chisq
p.value
1
Study
1
Inf
36.051
36.051
<0.0001
***
3
f39_gdm_new
1
Inf
32.027
32.027
<0.0001
***
4
BMI
1
Inf
316.807
316.807
<0.0001
***
5
Ethnicity_cauc
1
Inf
24.882
24.882
<0.0001
***
6
f10c_any_cig_1st_vst
1
Inf
2.618
2.618
0.1
ns
7
GA_samp
1
Inf
1.602
1.602
0.2
ns
2
Study:f39_gdm_new
1
Inf
4.361
4.361
0.04
*
GLUC3_mmol.L
model term
df1
df2
F.ratio
Chisq
p.value
1
Study
1
Inf
53.182
53.182
<0.0001
***
3
f39_gdm_new
1
Inf
4.345
4.345
0.04
*
4
BMI
1
Inf
11.449
11.449
0.0007
***
5
Ethnicity_cauc
1
Inf
0.718
0.718
0.4
ns
6
f10c_any_cig_1st_vst
1
Inf
0.028
0.028
0.9
ns
7
GA_samp
1
Inf
0.278
0.278
0.6
ns
2
Study:f39_gdm_new
1
Inf
1.558
1.558
0.2
ns
66.2.2 Model summary
Ratio of Geometric means (95% CI)
Prolactin
Var
Effect
P
(Intercept)
2.75 (2.39, 3.12)
<0.0001
Folate
-0.00 (-0.00, 0.00)
0.12
f39_gdm_newGDM
-0.11 (-0.35, 0.13)
0.36
StudySTOP
-0.08 (-0.21, 0.05)
0.23
GA_samp
0.14 (0.12, 0.16)
<0.0001
Folate:f39_gdm_newGDM
0.00 (-0.00, 0.00)
0.75
f39_gdm_newGDM:StudySTOP
0.16 (-0.07, 0.38)
0.17
Folate:StudySTOP
0.00 (-0.00, 0.00)
0.10
HPL
Var
Effect
P
(Intercept)
0.65 (0.46, 0.84)
<0.0001
Folate
-0.00 (-0.00, 0.00)
0.58
f39_gdm_newGDM
-0.11 (-0.23, 0.01)
0.07
StudySTOP
0.10 (0.03, 0.17)
0.004
GA_samp
0.29 (0.28, 0.30)
<0.0001
Folate:f39_gdm_newGDM
0.00 (-0.00, 0.00)
0.28
f39_gdm_newGDM:StudySTOP
0.06 (-0.05, 0.17)
0.31
Folate:StudySTOP
-0.00 (-0.00, 0.00)
0.89
GH2
Var
Effect
P
(Intercept)
-2.57 (-2.82, -2.32)
<0.0001
Folate
-0.00 (-0.00, 0.00)
0.37
f39_gdm_newGDM
-0.17 (-0.34, 0.00)
0.05
StudySTOP
-0.01 (-0.11, 0.08)
0.77
GA_samp
0.26 (0.25, 0.28)
<0.0001
Folate:f39_gdm_newGDM
0.00 (-0.00, 0.00)
0.65
f39_gdm_newGDM:StudySTOP
0.17 (0.00, 0.33)
0.05
Folate:StudySTOP
-0.00 (-0.00, 0.00)
0.89
Insulin
Var
Effect
P
(Intercept)
2.45 (1.99, 2.91)
<0.0001
Folate
-0.00 (-0.00, 0.00)
0.56
f39_gdm_newGDM
0.94 (0.44, 1.44)
0.0002
StudySTOP
-0.17 (-0.36, 0.02)
0.07
GA_samp
0.02 (-0.01, 0.05)
0.24
Folate:f39_gdm_newGDM
-0.00 (-0.01, 0.00)
0.27
f39_gdm_newGDM:StudySTOP
-0.42 (-0.98, 0.13)
0.14
Folate:StudySTOP
-0.00 (-0.00, 0.00)
0.24
Folate:f39_gdm_newGDM:StudySTOP
0.00 (-0.00, 0.01)
0.38
HOMA.IR
Var
Effect
P
(Intercept)
1.09 (0.60, 1.58)
<0.0001
Folate
-0.00 (-0.00, 0.00)
0.54
f39_gdm_newGDM
1.08 (0.52, 1.65)
0.0002
StudySTOP
-0.32 (-0.51, -0.12)
0.002
GA_samp
0.01 (-0.02, 0.04)
0.39
Folate:f39_gdm_newGDM
-0.00 (-0.01, 0.00)
0.18
f39_gdm_newGDM:StudySTOP
-0.51 (-1.13, 0.10)
0.10
Folate:StudySTOP
-0.00 (-0.00, 0.00)
0.25
Folate:f39_gdm_newGDM:StudySTOP
0.00 (-0.00, 0.01)
0.33
GLUC3_mmol.L
Var
Effect
P
(Intercept)
1.73 (1.63, 1.82)
<0.0001
Folate
-0.00 (-0.00, 0.00)
0.67
f39_gdm_newGDM
0.16 (0.03, 0.30)
0.02
StudySTOP
-0.15 (-0.18, -0.11)
<0.0001
GA_samp
-0.00 (-0.01, 0.00)
0.44
Folate:f39_gdm_newGDM
-0.00 (-0.00, -0.00)
0.03
f39_gdm_newGDM:StudySTOP
-0.07 (-0.19, 0.04)
0.20
Folate:StudySTOP
0.00 (-0.00, 0.00)
0.61
66.2.3 Estimated means
Estimated marginal means (or adjusted means) adjusted for GA at sampling.
Results are averaged over the levels of Serum folate concentration (nM) and may be misleading when interaction term is involved.
Prolactin
Study
f39_gdm_new
response
SE
df
lower.CL
upper.CL
SCOPE
non-GDM
95.27842
7.245025
92.02225
81.92307
110.8110
STOP
non-GDM
95.99562
6.888971
73.23520
83.20322
110.7548
SCOPE
GDM
87.47004
11.007528
554.68775
68.31356
111.9984
STOP
GDM
103.24476
9.012600
156.11767
86.89267
122.6741
HPL
Study
f39_gdm_new
response
SE
df
lower.CL
upper.CL
SCOPE
non-GDM
89.05209
2.458770
174.9519
84.32927
94.03941
STOP
non-GDM
98.36258
2.429469
113.9478
93.66564
103.29505
SCOPE
GDM
83.68200
4.640853
830.6800
75.05110
93.30545
STOP
GDM
98.04443
3.614067
443.9313
91.19280
105.41084
GH2
Study
f39_gdm_new
response
SE
df
lower.CL
upper.CL
SCOPE
non-GDM
2.333066
0.0707105
454.5683
2.198164
2.476248
STOP
non-GDM
2.286500
0.0564626
253.5503
2.177965
2.400443
SCOPE
GDM
2.021693
0.1569705
1368.5699
1.736068
2.354310
STOP
GDM
2.336972
0.1025856
821.6759
2.144042
2.547262
Insulin
Study
f39_gdm_new
response
SE
df
asymp.LCL
asymp.UCL
SCOPE
non-GDM
14.01040
0.7336892
Inf
12.64374
15.52480
STOP
non-GDM
10.80410
0.4091616
Inf
10.03120
11.63655
SCOPE
GDM
30.04116
4.0282239
Inf
23.09824
39.07099
STOP
GDM
17.98223
1.3989404
Inf
15.43916
20.94418
HOMA.IR
Study
f39_gdm_new
response
SE
df
asymp.LCL
asymp.UCL
SCOPE
non-GDM
3.389311
0.1887886
Inf
3.038775
3.780283
STOP
non-GDM
2.244756
0.0897830
Inf
2.075505
2.427809
SCOPE
GDM
7.879545
1.1696777
Inf
5.890398
10.540413
STOP
GDM
3.841241
0.3191235
Inf
3.264038
4.520515
GLUC3_mmol.L
Study
f39_gdm_new
response
SE
df
asymp.LCL
asymp.UCL
SCOPE
non-GDM
5.421737
0.0532507
Inf
5.318366
5.527117
STOP
non-GDM
4.708414
0.0380618
Inf
4.634402
4.783608
SCOPE
GDM
5.964490
0.3009833
Inf
5.402808
6.584566
STOP
GDM
4.810264
0.0606364
Inf
4.692875
4.930589
66.2.4 Comparisons
66.2.4.1 Within Groups
Effect for every 50 unit increase in Serum folate concentration (nM).
Hormone
Contrast
Study
f39_gdm_new
Ratio of Geometric means (95% CI)
P-value
Prolactin
Folate89.2 / Folate39.2
SCOPE
non-GDM
0.949 (0.888, 1.013)
0.1
Prolactin
Folate89.2 / Folate39.2
STOP
non-GDM
1.017 (0.964, 1.072)
0.5
Prolactin
Folate89.2 / Folate39.2
SCOPE
GDM
0.968 (0.846, 1.106)
0.6
Prolactin
Folate89.2 / Folate39.2
STOP
GDM
1.037 (0.927, 1.160)
0.5
HPL
Folate89.2 / Folate39.2
SCOPE
non-GDM
0.990 (0.956, 1.025)
0.6
HPL
Folate89.2 / Folate39.2
STOP
non-GDM
0.987 (0.959, 1.016)
0.4
HPL
Folate89.2 / Folate39.2
SCOPE
GDM
1.027 (0.955, 1.104)
0.5
HPL
Folate89.2 / Folate39.2
STOP
GDM
1.024 (0.962, 1.089)
0.5
GH2
Folate89.2 / Folate39.2
SCOPE
non-GDM
0.978 (0.932, 1.027)
0.4
GH2
Folate89.2 / Folate39.2
STOP
non-GDM
0.974 (0.936, 1.013)
0.2
GH2
Folate89.2 / Folate39.2
SCOPE
GDM
0.999 (0.904, 1.104)
1.0
GH2
Folate89.2 / Folate39.2
STOP
GDM
0.994 (0.913, 1.083)
0.9
Insulin
Folate89.2 / Folate39.2
SCOPE
non-GDM
0.971 (0.880, 1.072)
0.6
Insulin
Folate89.2 / Folate39.2
STOP
non-GDM
0.906 (0.850, 0.965)
0.002
Insulin
Folate89.2 / Folate39.2
SCOPE
GDM
0.848 (0.681, 1.056)
0.1
Insulin
Folate89.2 / Folate39.2
STOP
GDM
0.903 (0.767, 1.063)
0.2
HOMA.IR
Folate89.2 / Folate39.2
SCOPE
non-GDM
0.968 (0.870, 1.076)
0.5
HOMA.IR
Folate89.2 / Folate39.2
STOP
non-GDM
0.898 (0.840, 0.961)
0.002
HOMA.IR
Folate89.2 / Folate39.2
SCOPE
GDM
0.802 (0.624, 1.031)
0.09
HOMA.IR
Folate89.2 / Folate39.2
STOP
GDM
0.875 (0.739, 1.036)
0.1
GLUC3_mmol.L
Folate89.2 / Folate39.2
SCOPE
non-GDM
0.997 (0.981, 1.013)
0.7
GLUC3_mmol.L
Folate89.2 / Folate39.2
STOP
non-GDM
1.003 (0.986, 1.020)
0.7
GLUC3_mmol.L
Folate89.2 / Folate39.2
SCOPE
GDM
0.946 (0.895, 1.000)
0.05
GLUC3_mmol.L
Folate89.2 / Folate39.2
STOP
GDM
0.952 (0.915, 0.990)
0.01
66.2.4.2 Between Groups
Below are comparisons of the differences in the change in Serum folate concentration (nM) between groups. I.e. whether the change in Serum folate concentration (nM) are different between groups.